Proteins with High Structural Similarity can have Different Mechanical Unfolding Behaviors
نویسندگان
چکیده
منابع مشابه
Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?
By considering temperature effects on the mechanical unfolding rates of proteins and RNA, whose energy landscape is rugged, the question posed in the title is answered in the affirmative. Adopting a theory by Zwanzig [Zwanzig, R. (1988) Proc. Natl. Acad. Sci. USA 85, 2029-2030], we show that, because of roughness characterized by an energy scale epsilon, the unfolding rate at constant force is ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2444